期刊
TOXICOLOGY IN VITRO
卷 29, 期 2, 页码 314-319出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2014.11.009
关键词
Liposomes; MTT assay; Cell viability; Drugs
类别
资金
- Regione Autonoma della Sardegna [F71J11001220002]
The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay is commonly used to evaluate the cytotoxicity potential of drugs vehicled by liposomes. However, liposome delivering drugs could produce inconsistent values of MTT absorbance. On the basis of previous experiments demonstrating the MTT affinity for lipid droplets, this paper aims to show that empty-liposomes interfere, per se, on MTT assay due to its lipidic nature. This brings into question the use of MTT testing cytotoxicity when liposomes are involved in delivering drugs. (C) 2014 Elsevier Ltd. All rights reserved.
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