期刊
OSTEOPOROSIS INTERNATIONAL
卷 21, 期 12, 页码 2047-2055出版社
SPRINGER LONDON LTD
DOI: 10.1007/s00198-009-1167-8
关键词
BMD; Calcium; Cholecalciferol; Population-based; RCT
资金
- Finnish Cultural Foundation (Hulda Tossavainen Foundation)
- Sigrid Juselius Foundation
- Academy of Finland
- Kuopio University Hospital
- Leiras-Nycomed Ltd.
The Osteoporosis Risk Factor and Prevention-Fracture Prevention Study (OSTPRE-FPS) was a randomized population-based open trial (n=593). The supplementation group (n=287) received daily cholecalciferol 800 IU + calcium 1,000 mg for 3 years while the control group (n=306) received neither supplementation nor placebo. Daily vitamin D and calcium supplementation have a positive effect on the skeleton in ambulatory postmenopausal women. Introduction Vitamin D deficiency is common in the elderly, and vitamin D levels are associated with low bone mineral density (BMD). The working hypothesis was that vitamin D and calcium supplementation could prevent bone loss in ambulatory postmenopausal women. Methods The OSTPRE-FPS was a randomized population-based open trial with a 3-year follow-up in 3,432 women (aged 66 to 71 years). A randomly selected subsample of 593 subjects underwent BMD measurements. The supplementation group (n=287) received daily cholecalciferol 800 IU + calcium 1,000 mg for 3 years while the control group (n=306) received neither supplementation nor placebo. Results In the intention-to-treat analysis, total body BMD (n=362) increased significantly more in the intervention group than in the control group (0.84% vs. 0.19%, p=0.011). The BMD change differences at the lumbar spine (p=0.372), femoral neck (p=0.188), trochanter (p=0.085), and total proximal femur (p=0.070) were statistically nonsignificant. Analyses in compliant women (>= 80% of use) resulted in stronger and statistically significant effects at the total body and femoral regions. Conclusion Daily vitamin D and calcium supplementation have a positive effect on the skeleton in ambulatory postmenopausal women with adequate nutritional calcium intake.
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