期刊
OSTEOPOROSIS INTERNATIONAL
卷 21, 期 2, 页码 263-273出版社
SPRINGER LONDON LTD
DOI: 10.1007/s00198-009-0945-7
关键词
Bone density; Bone imaging; Bone structure
资金
- NIAMS NIH HHS [R01 AR049896, K24 AR052665, AR49896, R01 AR051376, K24 AR052665-05, R01 AR049896-01A2, AR051376] Funding Source: Medline
- NIDDK NIH HHS [DK069350, K23 DK080139, R01 DK069350] Funding Source: Medline
We compared microarchitecture and mechanical competence parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite-element analysis of radius and tibia to those measured by histomorphometry, micro-CT, and finite-element analysis of transiliac bone biopsies. Correlations were weak to moderate between parameters measured on biopsies and scans. HR-pQCT is a new imaging technique that assesses trabecular and cortical bone microarchitecture of the radius and tibia in vivo. The purpose of this study was to determine the extent to which microarchitectural variables measured by HR-pQCT reflect those measured by the gold standard, transiliac bone biopsy. HR-pQCT scans (Xtreme CT, Scanco Medical AG) and iliac crest bone biopsies were performed in 54 subjects (aged 39 +/- 10 years). Biopsies were analyzed by 2D quantitative histomorphometry and 3D microcomputed tomography (A mu CT). Apparent Young's modulus, an estimate of mechanical competence or strength, was determined by micro-finite-element analysis (A mu FE) of biopsy A mu CT and HR-pQCT images. The strongest correlations observed were between trabecular parameters (bone volume fraction, number, separation) measured by A mu CT of biopsies and HR-pQCT of the radius (R 0.365-0.522; P < 0.01). Cortical width of biopsies correlated with cortical thickness by HR-pQCT, but only at the tibia (R = 0.360, P < 0.01). Apparent Young's modulus calculated by A mu FE of biopsies correlated with that calculated for both radius (R = 0.442; P < 0.001) and tibia (R = 0.380; P < 0.001) HR-pQCT scans. The associations between peripheral (HR-pQCT) and axial (transiliac biopsy) measures of microarchitecture and estimated mechanical competence are significant but modest.
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