4.5 Article

Comprehensive summary - Predict-IV: A systems toxicology approach to improve pharmaceutical drug safety testing

期刊

TOXICOLOGY IN VITRO
卷 30, 期 1, 页码 4-6

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2014.09.016

关键词

Predict-IV; Systems toxicology; Cellular models; Liver; Kidney; Central nervous system (CNS)

资金

  1. EU [20222]

向作者/读者索取更多资源

This special issue of Toxicology in Vitro is dedicated to disseminating the results of the EU-funded collaborative project Profiling the toxicity of new drugs: a non animal-based approach integrating toxicodynamics and biokinetics (Predict-IV; Grant 202222). The project's overall aim was to develop strategies to improve the assessment of drug safety in the early stage of development and late discovery phase, by an intelligent combination of non animal-based test systems, cell biology, mechanistic toxicology and in silica modeling, in a rapid and cost effective manner. This overview introduces the scope and overall achievements of Predict-IV. (C) 2014 Elsevier Ltd. All rights reserved.

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