期刊
OSTEOARTHRITIS AND CARTILAGE
卷 27, 期 1, 页码 41-48出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2018.08.021
关键词
Intervertebral disc degeneration; Endogenous repair; Stem cells; Microenvironment; Migration; Cell death
资金
- National Key Research and Development Program of China [2016YFC1100100]
- Major Research Plan of National Natural Science Foundation of China [91649204]
- National Natural Science Foundation of China [81572204, 81501924]
Intervertebral disc (IVD) degeneration is frequently associated with Low back pain (LBP), which can severely reduce the quality of human life and cause enormous economic loss. However, there is a lack of long-lasting and effective therapies for IVD degeneration at present. Recently, stem cell based tissue engineering techniques have provided novel and promising treatment for the repair of degenerative IVDs. Numerous studies showed that stem/progenitor cells exist naturally in IVDs and could migrate from their niche to the IVD to maintain the quantity of nucleus pulposus (NP) cells. Unfortunately, these endogenous repair processes cannot prevent IVD degeneration as effectively as expected. Therefore, theoretical basis for regeneration of the NP in situ can be obtained from studying the mechanisms of endogenous repair failure during IVD degeneration. Although there have been few researches to study the mechanism of cell death and migration of stem/progenitor cells in IVD so far, studies demonstrated that the major inducing factors (compression and hypoxia) of IVD degeneration could decrease the number of NP cells by regulating apoptosis, autophagy, and necroptosis, and the particular chemokines and their receptors played a vital role in the migration of mesenchymal stem cells (MSCs). These studies provide a clue for revealing the mechanisms of endogenous repair failure during IVD degeneration. This article reviewed the current research situation and progress of the mechanisms through which IVD stem/progenitor cells failed to repair IVD tissues during IVD degeneration. Such studies provide an innovative research direction for endogenous repair and a new potential treatment strategy for IVD degeneration. (c) 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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