期刊
ARCHIVES OF MEDICAL SCIENCE
卷 11, 期 6, 页码 1145-1155出版社
TERMEDIA PUBLISHING HOUSE LTD
DOI: 10.5114/aoms.2015.56340
关键词
ear lobe crease; coronary artery disease; Frank's sign
The ear lobe crease (ELC) has been defined as a deep wrinkle that extends backwards from the tragus to the auricle. It has been proposed that ELC is a predictor of coronary artery disease (CAD). In this review, we consider the possible association between ELC and CAD. Our aim is to systematically address all the relevant evidence in this field. There are many studies that support an association between ELC and CAD. However, other studies did not find such an association. A recent meta-analysis supports the hypothesis that ELC could be a marker of CAD. However, several limitations raise doubts as to whether we should accept this link.
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