期刊
OSTEOARTHRITIS AND CARTILAGE
卷 20, 期 7, 页码 727-735出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2012.04.003
关键词
Osteoarthritis; Cartilage; T-2 mapping; Magnetic Resonance Imaging; Osteoarthritis Initiative
资金
- NIH [U01 AR059507, F32 AR059478]
- National Institutes of Health [N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262]
- Department of Health and Human Services
- Pfizer, Inc.
- Novartis Pharmaceuticals Corporation
- Merck Research Laboratories
- GlaxoSmithKline
- Foundation for the National Institutes of Health
Objective: The purpose of this study is to determine whether the mean and heterogeneity of magnetic resonance (MR) knee cartilage T-2 relaxation time measurements at baseline are associated with morphologic degeneration of cartilage, meniscus, and bone marrow tissues over 3 years in subjects with risk factors for osteoarthritis (OA). Design: Subjects with risk factors for OA (n = 289) with an age range of 45-55 years were selected from the Osteoarthritis Initiative (OAI) database. 3.0 Tesla MR images were analyzed using morphological gradings of cartilage, bone marrow and menisci whole-organ magnetic resonance imaging scores (WORMS scoring). A T-2 mapping sequence was used to assess the mean and heterogeneity of cartilage T-2 (gray level co-occurrence matrix texture analysis). Regression models were used to assess the relationship between baseline T-2 parameters and changes in morphologic knee WORMS scores over 3 years. Results: The prevalence of knee abnormalities in the cartilage (P < 0.0005), meniscus (P < 0.00001), and bone marrow significantly (P < 0.00001) increased from baseline to 3 years in all compartments combined. The baseline mean and heterogeneity of cartilage T-2 were significantly (P < 0.05) associated with morphologic joint degeneration in the cartilage, meniscus and bone marrow over 3 years. Conclusions: The prevalence of knee abnormalities significantly increased over 3 years; increased cartilage T-2 at baseline predicted longitudinal morphologic degeneration in the cartilage, meniscus, and bone marrow over 3 years ill subjects with risk factors for OA. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.
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