期刊
OSTEOARTHRITIS AND CARTILAGE
卷 20, 期 7, 页码 653-660出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2012.03.011
关键词
T2*; MRI; Cartilage; Hip; 3T; Histology
资金
- German Osteoarthritis Aid (Deutsche Arthrose-Hilfe e.V.)
Objective: To evaluate T2* values in various histological severities of osteoarthritis (OA). Method: Magnetic resonance imaging (MRI) and T2* mapping including a three-dimensional (3D) double-echo steady-state (DESS) sequence for morphological cartilage assessment and a 3D multiecho data image combination (MEDIC) sequence for T2* mapping were conducted in 21 human femoral head specimens with varying severities of OA. Subsequently, histological assessment was undertaken in all specimens to correlate the observations of T2* mapping with histological analyses. According to the Mankin score, four grades of histological changes were determined: grade 0 (Mankin scores of 0-4), grade I (scores of 5-8), grade II (scores of 9-10), and grade III (scores of 11-14). For reliability assessment, cartilage T2* measurements were repeated after 4 weeks in 10 randomly selected femoral head specimens. Results: T2* values decreased significantly with increasing cartilage degeneration (total P-values <0.001) ranging from 36.3 +/- 4.3 ms in grade 0 regions to 22.8 +/- 4.3 ms in regions with grade III changes. Pearson correlation analysis proved a fair correlation between T2* values and Mankin score (correlation coefficient = -0.362) that was statistically significant (P-value <0.001). Intra-class correlation (ICC) analysis demonstrated high intra-observer reproducibility for the T2* measurement (ICC: 0.949, P < 0.001). Conclusions: Given the advantages of the T2* mapping technique with no need for contrast medium, high image resolution and ability to perform 3D biochemically sensitive imaging, T2* mapping may be a strong addition to the currently evolving era of cartilage biochemical imaging. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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