期刊
TOXICOLOGICAL SCIENCES
卷 150, 期 1, 页码 54-63出版社
OXFORD UNIV PRESS
DOI: 10.1093/toxsci/kfv259
关键词
Aflatoxin B-1; lactic acid bacteria; microbiome; mycotoxins; next-generation sequencing; 16S rRNA sequencing
类别
资金
- Interdisciplinary Toxicology Program at the University of Georgia
- U.S. Agency for International Development via Peanut CRSP at University of Georgia [ECG-A-00-07-00001-00]
- National Institute of Health Fogarty International Center [1R24TW009489]
Aflatoxins are a group of potent foodborne toxicants naturally occurring in maize and groundnuts. Differential species-specific sensitivity to aflatoxins has been documented but cannot be fully explained by the differences in metabolism of these toxicants among animal species. Commensal microbial communities (microbiota) are critical to human and animal health, but few studies have assessed interactions between xenobiotic toxins and those microbiota, and its potential effects to humans and animals. Here, an exploratory dosing experiment was conducted to explore effects of Aflatoxin B-1 (AFB(1)) on the gut microbiota in a commonly used rat model. Male F344 rats were randomly divided into groups and treated with different concentrations of AFB(1). Microbial communities in fecal samples were assessed using 16S rRNA sequence analysis. We found that samples from the control group had a phylogenetically diverse community, and that increasing AFB(1) doses decreased this diversity but increased evenness of community composition. In addition, the gut microbiota from different samples was clustered according to their dosing regimens. There is no community shift at the phylum level but some lactic acid bacteria were significantly depleted by AFB(1). These findings suggested that AFB(1) could modify the gut microbiota in a dose-dependent manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据