期刊
OSTEOARTHRITIS AND CARTILAGE
卷 16, 期 1, 页码 83-89出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.joca.2007.05.013
关键词
articular cartilage; MRI; diffusion tensor imaging; compression; collagen; osteoarthritis
Objective: To demonstrate the use of diffusion tensor magnetic resonance micro-imaging to observe adaptations of Collagen fibres to mechanical compression in articular cartilage. Methods: Spin-echo and diffusion tensor images (156 x 156 gm in-plane resolution, 2 mm slice thickness) of bovine cartilage were obtained at a magnetic field of 7.0 T in relaxed and compressed states. The parameters determined were: T-2, maximum and mean diffusivity, direction of the maximum diffusion eigenvector and fractional anisotropy of diffusion. Results: A correlation was found between the compressive strain applied to the cartilage and the change in both magnitude and direction of the maximum diffusivity. Compression resulted in a decrease in both the maximum and mean eigenvalues, particularly in the surface and transitional zones, while the change in orientation of the eigenvectors corresponding to maximum diffusion was greatest in the transitional region. In this region, the average orientation of the principal eigenvectors with respect to the normal to the articular surface increased by up to 40 degrees, indicating that the collagen fibre bundles were oriented more parallel to the surface when compressed. Conclusions: Diffusion tensor imaging can be used to monitor the changes in the direction of the collagen fibres due to compression. It may form the basis of a new non-invasive approach to functional evaluation of cartilage, with potential applications in the diagnosis and treatment of osteoarthritis. (c) 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据