期刊
ORTHOPEDIC CLINICS OF NORTH AMERICA
卷 40, 期 2, 页码 235-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ocl.2009.01.004
关键词
Osteonecrosis; Statins; Avascular necrosis; Transplant; Incidence
类别
资金
- NIDDK NIH HHS [DK13083, P01 DK013083, P01 DK013083-35] Funding Source: Medline
The relationship between corticosteroids and osteonecrosis is well known. Limited data suggest that statins modulate cholesterol metabolism and may protect against osteonecrosis. The authors analyzed their prospective renal transplant database to determine if statin usage reduces the incidence of corticosteroid-related osteonecrosis and identified 2,881 renal transplantation patients who met the entry criteria. Among 338 patients on statins, 15 (4.4%) developed osteonecrosis, versus 180 of 2,543 (7%) patients who were not on statins. Osteonecrosis-free survival was similar in patients with and without statin exposure.
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