Very Simple and Highly Modular Synthesis of Ferrocene-Based Chiral Phosphines with a Wide Variety of Substituents at the Phosphorus Atom(s)

Chiral ferrocene-based phosphines with a wide variety of substituents at the phosphorus atom(s) have been simply and modularly synthesized by ortho lithiation of Ugi's amine and then reaction with PCl3 and finally treatment with Grignard or organolithium reagents.