期刊
ORGANOMETALLICS
卷 33, 期 19, 页码 5448-5456出版社
AMER CHEMICAL SOC
DOI: 10.1021/om500747m
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资金
- NSF [CHE-0748312]
- NIH [1R01GM098512-01]
- Alexander von Humboldt Foundation
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0748312] Funding Source: National Science Foundation
The chemo- and regioselectivity and functional group compatibility in gold and palladium cooperatively catalyzed cross-coupling reactions were determined in the synthesis of lactones; the selectivity in the gold and palladium dual-metal catalysis system was distinct from that available for the same class of substrates in systems with only gold catalysis or only palladium catalysis rather than dual catalysis. The dual-catalytic rearrangement reaction selectively promoted oxidative addition at the CO bond over the CBr bond, providing a useful CBr bond handle for downstream functionalization showcased via SuzukiMiyaura and Sonogashira coupling reactions. Product classes were expanded from isocoumarins to three previously unpublished ring classes: pyrone, indolepyrone, and furopyrone.
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