期刊
ORGANOMETALLICS
卷 33, 期 2, 页码 473-484出版社
AMER CHEMICAL SOC
DOI: 10.1021/om400786r
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资金
- National Science Foundation [CHE-1057792]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1057792] Funding Source: National Science Foundation
Iridium complexes containing CCC-pincer m-phenylene-bridged N-heterocyclic carbene ligands were examined as catalysts for alkene isomerization. Complexes containing either mesityl or adamantyl side groups were found to catalyze the isomerization of a number of alkenes to the internal isomers, including 1-octene, vinylcyclohexane, and allylbenzene. Mechanistic studies indicate a surprising dichotomy, apparently caused by ligand steric effects. For the mesityl-substituted catalyst, several lines of evidence provide strong support for isomerization via an iridium allyl hydride intermediate: (1) H-D crossover experiments indicate that 1,3-hydrogen migration is exclusively intramolecular, (2) the catalyst resting state, a pi-allyl hydride species, was isolated and serves as a kinetically competent catalyst, (3) NMR experiments indicate that the pi-allyl hydride resting state undergoes reversible C-H reductive elimination that is rapid relative to catalytic turnover, and (4) kinetic studies indicate that the isomerization reaction is first order in substrate and catalyst, consistent with turnover-limiting ligand substitution. H-D crossover experiments for alkene isomerization catalyzed by the adamantyl-substituted complex show selectivity for a 1,3-deuterium shift, as well as the intermolecular transfer of hydrogen. These results are consistent with an insertion/elimination mechanism proceeding selectively through a secondary metal-alkyl or with a pi-allyl-type mechanism with an unknown pathway for intermolecular hydrogen crossover.
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