Reactivity of Lewis Acid Activated Diaza- and Dithiaboroles in Electrophilic Arene Borylation

Hydride abstraction from N,N'-bis(adamantyl)1-hydrido-1,3,2-benzodiazaborole with catalytic [Ph3C][closo-CB11H6Br6] resulted in a low yield of arene borylation and a major product derived from migration of both adamantyl groups to the arene backbone. In contrast, the related arylsubstituted diazaborole N,N'-(2,6-diisopropylphenyl)-1bromo-1,3,2-diazaborole did not borylate benzene or toluene, being resistant to halide abstraction even with strong halide acceptors: e.g., [Et3Si][closo-CB11H6Br6]. The reactivity disparity arises from greater steric shielding of the boron p(z) orbital in the 2,6-diisopropylphenyl-substituted diazaboroles.Boron electrophiles derived from 1-chloro-1,3,2-benzodithiaborole ((CatS(2))BCl) are active for arene borylation, displaying reactivity between that of catecholato- and dichloro-boron electrophiles. [(CatS(2))B(NEt3)][AlCl4] is significantly less prone to nudeophile-induced transfer of halide from [AlCl4](-) to boron compared to catecholato and dichloro borocations, enabling it to borylate arenes containing nucleophilic -NMe2 moieties in high conversion (e.g., N,N,4-trimethylaniline and 1,8-bis(dimethylamino)naphthalene). Calculations indicate that the magnitude of positive charge at boron is a key factor in determining the propensity of chloride transfer from [AlCl4]- to boron on addition of a nucleophile.