期刊
ORGANOMETALLICS
卷 31, 期 19, 页码 6843-6850出版社
AMER CHEMICAL SOC
DOI: 10.1021/om300671j
关键词
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资金
- NSF [CHE-0748312, NSF-201015893, CHE-0840513]
- NIH [1R01GM098512-01]
- University of California, Irvine
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0748312] Funding Source: National Science Foundation
A vinyl aziridine activation strategy cocatalyzed by palladium(0) and a gold(I) Lewis acid has been developed. This rearrangement installs a C-C and a C-N bond in one synthetic step to form pyrrolizidine and indolizidine products. Two proposed mechanistic roles for the gold cocatalyst were considered: (1) carbophilic gold catalysis or (2) azaphilic gold catalysis. Mechanistic studies support an azaphilic Lewis acid activation of the aziridine over a carbophilic Lewis acid activation of the alkene.
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