Organometallic Complexes for SPECT Imaging and/or Radionuclide Therapy

This article reviews Re and Tc organometallic chemistry and radiochemistry, focusing on the most relevant aspects to design radiotools for molecular imaging and therapy. The review comprises an overview of organometallic Re and Tc complexes with relevance to the field, particularly M(I) tricarbonyl complexes stabilized by a huge variety of ligands. These include Werner type chelators, cyclopentadienyls, carboranes, and poly(mercaptoazolyoborates, which permitted the hitherto unprecedented use of M-C and M-H bonds. The most relevant biomolecules labeled with the different organometallic cores will also be reviewed, as well as the opportunities offered by the tricarbonyl approach to design high-performance perfusion agents.