期刊
ORGANOMETALLICS
卷 31, 期 16, 页码 5800-5809出版社
AMER CHEMICAL SOC
DOI: 10.1021/om300359a
关键词
-
资金
- Deutsche Forschungsgemeinschaft [FOR 630]
- Fonds der Chemischen Industrie
A series of racemic phosphoryloxy-substituted (eta(4)-cyclohexadiene)Fe(CO)(3) complexes was synthesized by exploiting the O-phosphorylation of (dienol)Fe(CO)(3) intermediates generated in situ from the corresponding triisopropylsiloxy-protected complexes. The phosphorylated products were fully characterized by spectroscopic methods, including single-crystal X-ray diffraction in four cases. Monodeprotection of two dimethyl phosphate derivatives with trimethylamine led to the tetramethylammonium salts of the (cyclohexadienyl methyl phosphate)Fe(CO)(3) complexes. These compounds are the first water-soluble enzyme-trigged CO-releasing molecules (ET-CORMs). The phosphatase-induced CO release was monitored by means of GC. The biological activity was assessed in different cellular assays. The compounds were shown to be only slightly toxic, and a moderate anti-inflammatory potential was determined in an assay based on the inhibition of inducible NO synthase (iNOS)-induced NO production.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据