期刊
ORGANOMETALLICS
卷 30, 期 24, 页码 6718-6725出版社
AMER CHEMICAL SOC
DOI: 10.1021/om200933b
关键词
-
资金
- MICINN [CTQ2008-00950/BQU]
- DURSI [2009GR623]
- Consolider Ingenio [CSD2006-0003]
- ICIQ Foundation
- ICREA Funding Source: Custom
Two new chiral cationic rhodium(I) complexes derived from electron-rich dicyclohexylphosphine-phosphite ligands were prepared from enantiopure Sharpless epoxy ethers. The best-performing catalyst system, which bears a less bulky methyl ether moiety, exhibited remarkably high enantioselectivity (up to 99% cc) and reactivity (up to >2500 TON) in asymmetric hydrogenation reactions of various functionalized alkenes (alpha-(acylamino)acrylates, itaconic acid derivatives, a-substituted enol esters and alpha-arylenamides). Our synthetic methodology has been successfully applied to the enantioselective synthesis of the antiepileptic drug (R)-lacosamide (Vimpat).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据