Pressurized Sample Infusion for the Continuous Analysis of Air- And Moisture-Sensitive Reactions Using Electrospray Ionization Mass Spectrometry

Air- and moisture-sensitive compounds pose handling difficulties for chemists requiring mass spectrometric analysis. A simple pressurized sample infusion (PSI) system for electrospray ionization mass spectrometry using a Schlenk flask is presented, which allows straightforward one-off analyses as well as continuous reaction monitoring at any temperature up to the boiling point of the solvent.