In an effort to develop more active catalysts for the intramolecular hydroamination of amino alkenes, we have investigated the application of sterically hindered mono(phosphines) as supporting ligands for platinum-catalyzed hydroamination. Here we demonstrate that mixtures of PtCl2 and di(tertbutyl)o-biphenyl phosphines such as P(t-Bu)(2)[2-(2-NMe2C6H4)C6H4] catalyze the hydroamination of 4-pentenyl and 5-hexenyl amines at 60-80 degrees C. This catalyst system tolerates a number of functional groups and catalyzes the cyclization of unsubstituted amino alkenes.
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