期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 19, 期 1, 页码 315-319出版社
AMER CHEMICAL SOC
DOI: 10.1021/op500338d
关键词
-
An enantioselective and robust synthetic process to obtain a useful intermediate for the beta 2-adrenergic receptor agonist is described. Asymmetric transfer hydrogenation of ketone 1c by (S,S)-3b (Ms-DENEB) afforded chiral alcohol 2c in 71% isolated yield and 99% ee. The deprotection completed the synthesis of (R)-5 in 41% overall yield from 1b, which is readily commercially available.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据