期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 18, 期 8, 页码 1002-1009出版社
AMER CHEMICAL SOC
DOI: 10.1021/op500102h
关键词
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资金
- CNRS France
- Bayer S.A.S.
The synthesis of 3,5-bis(fluoroalkyl)-pyrazoles as novel agrophores is described. Commercially available fluoroacetoacetates are treated with BF3-activated TFEDMA affording in a straightforward one-pot sequence pyrazole carboxylates in good yields and with excellent regioselectivity. The carboxylate intermediates have been converted into the corresponding pyrazolic acids and submitted to decarboxylation, affording valuable building blocks for the design of novel bioactive ingredients. The found process is suitable for scale up and preparation of compounds in kilogram quantity.
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