期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 18, 期 8, 页码 928-933出版社
AMER CHEMICAL SOC
DOI: 10.1021/op5001226
关键词
-
资金
- National Natural Science Foundation of China [21176222]
- Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals
A novel process for the preparation of fluticasone propionate (1), a corticosteroid, is reported. In this paper, compound 2 was used as starting material to prepare 6 by using NaClO or NaBrO which was much cheaper than H5IO6 as an oxidizing agent. Furthermore, toxic, expensive, and pollutive BrCH2F was replaced by AgNO3 and Selectfluor in decarboxylative fluorination.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
