期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 17, 期 1, 页码 145-151出版社
AMER CHEMICAL SOC
DOI: 10.1021/op300248y
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资金
- Lek Pharmaceuticals, d.d.
In this report we present a flow photochemical bromination of a 5-methyl-substituted pyrimidine precursor of rosuvastatin. The study demonstrated that the reaction productivity can be increased markedly with a flow-mode approach compared to a batch-mode synthesis. Indeed, reaction times can be significantly shortened from a range of hours to a range of minutes. Moreover, in addition to process intensification, the study demonstrated that significantly lower overall levels of side products are obtained when photochemical bromination is conducted in a flow mode.
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