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Asymmetric and Diastereoselective Conjugate Addition Reactions: C-C Bond Formation at Large Scale

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ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 16, 期 7, 页码 1258-1272

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AMER CHEMICAL SOC
DOI: 10.1021/op200381w

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Asymmetric and diastereoselective conjugate addition reactions are discussed from an industrial perspective including examples of (1) Lewis acid/Bronsted base catalysis, (2) phase transfer catalysis, (3) organocatalysis, and (4) transition metal/ligand catalysis with organometallic reagents.

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