期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 16, 期 3, 页码 512-517出版社
AMER CHEMICAL SOC
DOI: 10.1021/op2003216
关键词
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An efficient process for synthesizing and isolating a new investigative anticancer agent, 1-bromoacetyl-3,3-dinitroazetidine, is described. The reaction entails a sequence of oxidative nitration followed by acylative dealkylation. The methods reported give 50-60-g batches of high-purity product without a designated purification step. The reaction conditions have been designed to mitigate the safety concerns associated with gem-dinitroazetidines. Some observations on the acylative dealkylation mechanism are discussed.
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