期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 16, 期 3, 页码 435-441出版社
AMER CHEMICAL SOC
DOI: 10.1021/op200329x
关键词
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A general procedure for the copper-catalyzed regioselective ring-opening of epoxides with Grignard reagents is described. The procedure developed provides robust reaction conditions which limit the formation of impurities and has been applied successfully using a series of epoxides and Grignard reagents to provide the desired products in >90% yield with excellent regioselectivity and purity.
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