期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 15, 期 4, 页码 783-787出版社
AMER CHEMICAL SOC
DOI: 10.1021/op100338z
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A flow chemistry method for the synthesis of pyrroles was developed. The method was optimized in 0.13 to 7 mu L microreactors in continuous flow, reaching yields of nearly 100%. Subsequently, the method was scaled up in continuous flow using a 9.6-mL internal volume, glass, microstructured flow reactor, leading to production of a pyrrole derivative at a rate of 55.8 g per hour.
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