Efficient Screening and Library Generation in Parallel C-C Coupling Reactions Mediated by Organosilica SiliaCat Palladium Catalysts

Organosilica SiliaCat palladium catalysts applied to the conversion of widely different substrates in Suzuki, Sonogashira, and Heck coupling reactions run in a parallel synthesizer enable quick screening of the reaction system with identification of the best reaction conditions and rapid library generation.