期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 16, 期 5, 页码 1131-1140出版社
AMER CHEMICAL SOC
DOI: 10.1021/op200180t
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A scalable process for the preparation of 4,4,5,5-tetramethyl-2-(3-trimethylsilyl-2-propynyl)-1,3,2-dioxaborolane from trimethylsilylpropyne, isopropyl pinacol borate, and n-butyllithium is described. Problems associated with implementing a typical aqueous workup and batch process into production due to borolane ate equilibration and protonolysis are presented. To address these issues, a continuous-flow and distillation process was developed which efficiently produced 297 kg of the key propargylation reagent.
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