期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 14, 期 5, 页码 1162-1168出版社
AMER CHEMICAL SOC
DOI: 10.1021/op100121s
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Process development towards the improvement of the manufacturing process of casopitant mesylate (a drug developed by GlaxoSmith Kline with activity on the central nervous system) identified a dynamic kinetic resolution opportunity for the improvement of the yield. In this paper, the application of quality by design principles to the DKR is presented together with the issues that were faced during different scale-ups and the at-scale solutions that were implemented.
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