期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 14, 期 4, 页码 912-917出版社
AMER CHEMICAL SOC
DOI: 10.1021/op100139f
关键词
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The triple reuptake inhibitor, GSK1360707, was synthesized via an efficient, scalable route, which features a vinyl triflate Suzuki coupling followed by a single-step, double alkylative cyclopropanation with a dihalomethane. Also, a mechanistic understanding of the Suzuki reaction (as it relates to the control of a polychlorinated biphenyl impurity) is discussed.
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