期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 13, 期 5, 页码 911-914出版社
AMER CHEMICAL SOC
DOI: 10.1021/op900152e
关键词
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资金
- Dutch Science Foundation (NWO)
- European commission [HPRN-CT-2001-00182]
Using a cascade of six centrifugal contactor separators in a countercurrent liquid-liquid extraction mode allowed the separation of one of the enantiomers of 3,5-dinitrobenzoyl-leucine in 55% yield and 98% ee using a catalytic amount of a chiral host compound based on a cinchona alkaloid, This method allows the preparation of kilograms of enantiopure material in table-top-sized equipment that can be operated in a fume cupboard. The methodology can be easily scaled up to ton amounts as large-volume centrifugal contactor separators are commercially available as well.
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