期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 13, 期 2, 页码 292-296出版社
AMER CHEMICAL SOC
DOI: 10.1021/op8002097
关键词
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A general and straightforward strategy for enzymatic resolution of N-substituted-beta-proline has been successfully designed and developed in our research laboratories. A first affinity screen is followed by ratio enzyme/substrate optimization to source our chemistry groups N-substituted-beta-proline in kilogram scale in an efficient and cost-effective way.
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