期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 13, 期 3, 页码 510-518出版社
AMER CHEMICAL SOC
DOI: 10.1021/op800308t
关键词
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An efficient, expedient synthesis of BMS-561392, 1, which enabled rapid delivery of drug substance for clinical development is described. The key features of the synthesis include an efficient synthesis of a phenolic alpha,alpha-disubstituted amino ester via carbon alkylation without protection of the phenol, an effective enzymatic resolution of this racemic amino ester, and a process for the preparation of a hydroxamic acid drug substance with undetectable levels of hydroxylamine.
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