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Elemental fluorine. Part 21. Direct fluorination of benzaldehyde derivatives

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ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 12, 期 2, 页码 339-344

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AMER CHEMICAL SOC
DOI: 10.1021/op700194r

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Direct fluorination of a range of benzaldehyde derivatives gives mixtures of fluorobenzaldehyde and benzoyl fluoride products in ratios that depend upon the nature of the ring substituent. Electron-withdrawing substituents give predominantly benzoyl fluoride derivatives, whereas electron-donating substituents lead to fluoroarene systems. Separation of ring-fluorinated products can be easily accomplished by esterification of the benzoyl fluoride side products. Scale-up of these processes to provide significant quantities of appropriate fluorobenzaldehyde systems has also been achieved using. continuous flow techniques.

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