Transition metal-catalyzed carbon-carbon bond formation Suzuki, Heck, and Sonogashira reactions using microwave and microtechnology

The fast growing field of microwave and microreactor technology has a significant impact on scaling up when combined with microwave irradiation for a wide variety of transition metal-catalyzed reactions. The combination of reactor design with immobilisation techniques is very important for the flow process, allowing maximal interaction between reagents and a catalyst with no clogging problem. In this review, we have presented the scale-up possibilities for a variety of transition metal-catalyzed C-C bond-forming reactions applying microwave heating and microtechnology.