期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 12, 期 6, 页码 1104-1113出版社
AMER CHEMICAL SOC
DOI: 10.1021/op800062d
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A six-step synthetic route to the CCR-5 receptor antagonist Maraviroc (UK-427,857) (1) has been developed and demonstrated at scale in a pilot plant. The route has supported four Pilot-Plant campaigns and has produced multikilogram quantities of 1. Continued development of the synthetic route has resulted in a robust process with improved throughput compared to that of the original synthesis (Haycock-Lewandowski, S. J.; Mawby, N. J.; Wilder, A.; Ahman, J. Org. Process Res. Dev. 2008, 12, 1094-1103).
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