期刊
ORGANIC LETTERS
卷 20, 期 18, 页码 5559-5563出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02207
关键词
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资金
- CAMS Initiative for Innovative Medicine [CAMS-I2M-1-010]
- NSF [MRI 1338056]
- National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health (NIH) [P20GM104932]
- National Institutes of Health (NIH) National Center for Research Resources [C06RR14503]
- NCCIH [R01AT007318]
- CSC
- Cooper Family
- Abney Foundation
Kadsuraols A-C (1-3), which are tetrahydrocyclobutaphenanthrofuranone-type lignans with a new carbon skeleton comprising a four-membered ring across C-1'-C-8, have been isolated from the roots of Kadsura longipedunculata. Their structures and absolute configurations were unambiguously determined using nuclear magnetic resonance, X-ray diffraction crystallography, DP4+ calculations, and computed and experimental electronic circular dichroism spectra. Kadsuraol C (3) exhibited hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity. The compounds showed no cytotoxicity at 10 mu M in a zone assay.
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