4.8 Article

A Protocol To Transform Sulfones into Nitrones and Aldehydes

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ORGANIC LETTERS
卷 20, 期 18, 页码 5789-5793

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02483

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  1. Spanish Government [CTQ2012-35957, CTQ2016-78779-R]

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A simple method to transform sulfones into nitrones and therefore into the corresponding carbonyl derivatives has been developed. Some examples demonstrate that it is a new reliable and versatile reaction in the toolbox of sulfones that has great synthetic potential. NMR and computational studies were used to elucidate the mechanism.

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