期刊
ORGANIC LETTERS
卷 20, 期 16, 页码 4970-4974出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02088
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资金
- National Natural Science Foundation of China [21502043]
- National Key Research and Development Program of China [2016YFA0501403]
- Natural Science Foundation of Shandong Province [ZR2017JL011]
- Special Funds for the Development of Strategic Emerging Industries in Shenzhen [JCYJ20170817110526264]
- Qingdao University
A catalyst-controlled diastereodivergence is described for the enantioselective conjugate addition of o-hydroxyphenyl-substituted p-QMs with 5H-thiazol-4-ones. The reactions were enabled by two chiral complementary, nonenantiomeric catalysts to furnish a series of adducts possessing vicinal sulfur-fiinctionalized quaternary and tertiary stereocenters in high yields with excellent asymmetric induction. Moreover, o-QMs generated in situ from o-hydroxybenzyl alcohols were also compatible.
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