期刊
ORGANIC LETTERS
卷 20, 期 17, 页码 5466-5469出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02382
关键词
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资金
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Fundamental Research Funds for the Central Universities [201822019, 201562016]
- Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02, 2016ASKJ08-02]
- City of Qingdao [2017-CXZX01-3-6]
Three new derivatives, anthranosides A-C (1-3), were discovered from a marine sponge-derived actinomycete Streptomyces sp. CMN-62. Their structures including absolute configurations were elucidated using MS and NMR spectroscopic data, X-ray single-crystal diffraction analysis, and chemical synthesis. Compounds 1 and 2 are epimers composed by linking the anthranilate unit to the fructofuranose moiety via a carbon-nitrogen bond, while 3 possessed a unique indole-containing scaffold. All compounds were tested for cytotoxicity, anti-influenza H1N1 virus, and NF kappa B inhibitory activities, and 3 showed anti-influenza activity. A possible Amadori rearrangement-based biosynthetic pathway was proposed to generate compounds 1-3.
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