期刊
ORGANIC LETTERS
卷 20, 期 19, 页码 6135-6139出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b02591
关键词
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资金
- NSFC [21620102003, 21772119]
- STCSM [15JC1402200]
- SHMEC [201701070002E00030]
A new type of ferrocene-based phosphine-oxazoline ligand has been prepared over a few simple steps. An iridium complex of this ligand is air stable and exhibits excellent performance for the asymmetric hydrogenation of simple ketones (up to 98% yield, up to 99% ee, and 20 000 S/C). Exo-alpha,beta-unsaturated cyclic ketones could be regiospecifically hydrogenated to give chiral allylic alcohols with good results. This study indicates that P,N-ligands can also efficiently promote Ir-catalyzed asymmetric hydrogenation without NH-hydrogen-bonding assistance.
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