期刊
ORGANIC LETTERS
卷 16, 期 18, 页码 4900-4903出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol5024129
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资金
- University of York
- EPSRC [EP/J000124/1]
- EPSRC [EP/J000124/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/J000124/1] Funding Source: researchfish
A double C-H, Ar-H coupling process for the conversion of bis-anilides into spirocyclic bis-oxindoles, enabling the concomitant formation of two all-carbon quaternary centers at oxindole 3-positions in a diastereoselective manner, is described. The optimum cyclization conditions utilize stoichiometric Cu(OAc)(2).H2O/KOtBu in DMF at 110 degrees C and have been applied to prepare a range of structurally diverse bis-spirooxindoles in fair to good yields (28-77%); the method has also been extended to prepare bis-oxindoles linked by a functionalized acyclic carbon chain.
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