期刊
ORGANIC LETTERS
卷 16, 期 24, 页码 6436-6439出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol503266q
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资金
- National Natural Science Foundation of China [21272230]
- Western Light Talent Culture Project
The first organocatalytic asymmetric synthesis of a spirooxindole skeleton incorporated with a cyclobutane moiety has been successfully developed on the basis of H-bond-directing dienamine activation. Structurally complex spirocyclobutyl oxindoles, which possess four contiguous stereocenters, including one spiro quaternary center, were obtained in good yields (up to 83%) with excellent beta,gamma-regioselectivity (>19:1) and stereocontrol (up to >19:1 dr and 97% ee).
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