期刊
ORGANIC LETTERS
卷 16, 期 13, 页码 3528-3531出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol501479t
关键词
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资金
- MEXT (Japan)
- JSPS
- Grants-in-Aid for Scientific Research [25810057] Funding Source: KAKEN
A novel catalytic cyclization reaction of alkynyl alpha-ketoanilide was developed by utilizing the [1,2]-phospha-Brook rearrangement. This reaction involves the generation of an amide enolate via the umpolung process, that is the addition of dialkyl phosphite to a keto moiety followed by the [1,2]-phospha-Brook rearrangement, and the subsequent intramolecular addition of the enolate to an alkyne to afford 3,4-dihydro-2-quinolone derivatives. Under high-temperature reaction conditions, further rearrangement of the allylic phosphate moiety occurs to provide 2-quinolone derivatives.
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