4.8 Article

Copper-Catalyzed Intramolecular Oxytrifluoromethylthiolation of Unactivated Alkenes

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ORGANIC LETTERS
卷 16, 期 20, 页码 5390-5393

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AMER CHEMICAL SOC
DOI: 10.1021/ol502624z

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  1. NSFC [21202072, 21102141, 21432003]
  2. Fundamental Research Funds for the Central Universities [860976, 861188]

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A mild, versatile, and convenient method for efficient intramolecular oxytrifluoromethylthiolation of unactivated alkenes catalyzed by Cu(OAc)(2) has been developed. The reactions were carried out under aerobic conditions and formed a variety of isoxazolines bearing a -SCF3 substituent.

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