期刊
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卷 16, 期 10, 页码 2602-2605出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol500670h
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资金
- DST-India
- CSIR-India
- DST Fast Track Scheme
An intramolecular dehydrogenative (sp(3))C-O bond formation in salicylamides can be initiated by an active Cu/O-2 species to generate pharamaceutically relevant dihydro-oxazinones. Experimental findings suggest that stereoelectronic parameters in both coupling partners are controlling factors for site selectivity in bond formation. Mechanistic investigations including isotope labeling, kinetic studies helped to propose a catalytic cycle. The method provides a convenient synthesis of an investigational new medicine CX-614, which has potential in finding treatment for Parkinson's and Alzheimer's diseases.
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