期刊
ORGANIC LETTERS
卷 16, 期 12, 页码 3284-3287出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol501290p
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资金
- National Natural Science Foundation of China [21072030]
- Research Fund for the Doctoral Program of Higher Education of China [20123514110003]
- SRF for ROCS, SEM, China [2012-1707]
- Fuzhou University [022318, 022494]
The CF3S-substituted moiety serves as an important structural element in many bioactive molecules. A versatile copper catalyst that allowed for trifluoromethylthiolation of primary and secondary alpha-bromoketones is described. The reaction with readily available elemental sulfur and CF3SiMe3 afforded a broad scope and moderate to good yields of alpha-trifluoromethylthio-substituted ketones. This procedure represents a very operationally simple yet powerful strategy for the synthesis of alpha-trifluoromethylthio-substituted ketones, a useful and versatile class of synthetic synthons.
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